SOLUBLE FORMS OF PD-L1 AND PD-1 AS PROGNOSTIC AND PREDICTIVE MARKERS OF SUNITINIB EFFICACY IN PATIENTS WITH METASTATIC CLEAR CELL RENAL CELL CARCINOMA

Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma

Metastatic clear cell renal cell carcinoma (mccRCC) benefits from several treatment options in the first-line setting with VEGFR inhibitors and/or immunotherapy including anti-PD-L1 or anti-PD1 agents.Identification of predictive biomarkers is highly needed to optimize patient care.Circulating markers could reflect the biology of metastatic disease

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The Acute Red Eye

Audience: This modified team-based learning (mTBL) exercise is appropriate for junior or senior emergency medicine learners.Introduction: The acute red eye is a common chief complaint in the emergency department.It is essential that the emergency physician be knowledgeable about the differential diagnosis for almanac sunshine and opportunity the ac

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Complexity: a new paradigm for fracture mechanics

The so-called Complexity Sciences are a topic of fast growing interest inside the scientific community.Actually, researchers did not come to a definition of complexity, since it manifests itself in so many different ways [1].This field itself is not a single discipline, but rather a heterogeneous amalgam of different techniques of mathematics and s

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