Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma

Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma

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Metastatic clear cell renal cell carcinoma (mccRCC) benefits from several treatment options in the first-line setting with VEGFR inhibitors and/or immunotherapy including anti-PD-L1 or anti-PD1 agents.Identification of predictive biomarkers is highly needed to optimize patient care.Circulating markers could reflect the biology of metastatic disease.Therefore, we evaluated soluble forms of PD-L1 (sPD-L1) and PD-1 (sPD-1) in mccRCC patients.

The levels of mcclelland reclining sofa sPD-L1 and sPD-1 were evaluated from plasma samples of mccRCC patients before they received a first-line treatment (T0) by the VEGFR inhibitor sunitinib (50 patients) or by the anti-VEGF bevacizumab (37 patients).The levels of sPD-L1 and sPD-1 were correlated to clinical parameters and progression-free survival (PFS).High levels of sPD-1 or sPDL1 were not correlated to PFS under bevacizumab while they were independent prognostic factors of PFS in the sunitinib group.Patients with high T0 plasmatic levels of sPD-L1 had a shorter PFS (11.

3 vs 22.5 months, p =.011) in the sunitinib group.Equivalent shorter PFS was found with high levels of sPD-1 (8.

6 vs 14.1 months, p almanac sunshine and opportunity =.009).mccRCC patients with high plasmatic levels of sPD-L1 or sPD-1 are poor responders to sunitinib.

sPD-L1 or sPD-1 could be a valuable tool to guide the optimal treatment strategy including VEGFR inhibitor.